MACROCYCLIC COMPLEXES 1 10 PHENANTHROLINE MOETIY PDF

MACROCYCLIC COMPLEXES 1 10 PHENANTHROLINE MOETIY PDF

Abstract–Infra-red spectra of twenty two metalphenanthroline perchlorates together with spectra of the free ligand, its hydrate and perchlorate salt have. Energy-Resolved Collision-Induced Dissociation Studies of 1,Phenanthroline Complexes of the Late First-Row Divalent Transition Metal Cations. A61K51/ Organic compounds complexes or complex-forming .. Embodiment The conjugate of any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 and 9, For example, in case the first targeting moiety is targeting NTR1 the first targeting moetiy is Such chelators include, but are not limited to linear, macrocyclic.

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In a preferred embodiment of the conjugate of the invention R8 of the adapter moiety is – CH2 n – and n is any integer from 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10, preferably n is 5. The conjugate of any one of embodiments 1 to 62, wherein the second targeting moiety TM2 is targeting a target different from the target targeted by the first targeting moiety.

In an embodiment and as preferably cpmplexes herein, a therapeutically active compound is a compound which phenanthrkline suitable for or useful in the treatment of a disease.

In other words, the first reactive group can be provided by either the first moiety or the second moiety under the proviso that the second reactive group is either provided by the second moiety or the first moiety, so that in each case the necessary reactive groups are present or are formed, respectively, allowing the forming of the linkage. The method of embodimentwherein the conjugate comprises a diagnostically active agent, whereby the agent is preferably a radionuclide.

Silverman, Academic Press Ltd. Therefore, an optimal compound and even more so a radiolabeled version thereof suitable for diagnosis and therapy, respectively, of a disease is a matter of luck rather than of a rational and predictable development process.

In an embodiment the cartilaginous fish is shark. Reddish-brown homogeneous solution was obtained. Depending on the characteristics of the first targeting moiety of the conjugate of the invention in. Indexed in Science Citation Mmacrocyclic Expanded. The con ugate of the invention comprises at least one compound of formula 2. It is within the present invention that such stability of the further targeting moiety is shown by any embodiment of such further targering moiety.

The preferred type of adapter moieties in one embodiment are amino acids, or activated forms thereof. In an embodiment and as preferably used herein, a theragnostically active compound is a compound which is suitable for or useful in both the diagnosis and therapy of a disease.

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The effector bearing agonist binds to the receptor and, upon binding to the receptor, the effector bearing agonist is internalized by the receptor and the effector bearing agonist thus trapped in the target cell. In an embodiment of the conjugate of the invention such conjugate is internalized by a cell, whereby preferably such internalization renders the effector, i.

Phenanthroline – Wikipedia

The analyzed results showed that the stability constant values obtained for and were the same at all molar ratios. In accordance with the function of an adapter moiety in a conjugate of the invention, the backbone of such adaptor moiety can, in principle, be quite diverse as long as such backbone of the adaptor moiety does not pehnanthroline with the synthesis and use, respectively, of the conjugate of the invention. Thyrotropin alfa TSH thyrotropin.

The conjugate of any one of embodiments 1 to 75, wherein the targeting moiety is different from a glycoside. It is a white solid that is soluble in organic solvents. This enables the ligand exchange rates of ruthenium complexes to be close to those of cellular processes which make them suitable for therapeutic applications.

View at Google Scholar E. In an embodiment and as preferably used herein, C 2 -C 5 alkylidene means each and individually any of ethane- 1,2-diyl, propane- 1,3 -diyl, propane- 1,2-diyl, butane- 1,4-diyl, butane- 1,3 -diyl, butane- 1,2-diyl, 2-m ethyl-propane- 1,2-diyl, 2-methyl-propane-l,3-diyl, pentane- 1,5-diyl, pentane- 1,4-diyl, pentane- 1,3 -diyl, pentane- 1,2-diyl, pentane-2,3-diyl, pentane-2,4-diyl and any other branched isomer with 5 carbon atoms, preferably C 2 – Cs alkylidene means each and individually any of ethane- 1,2-diyl, propane- 1,3-diyl, butane.

In a further embodiment of the conjugate of the invention a compound of formula 2in any of its embodiments, is present in the conjugate of the invention as targeting moiety Moettiy. It is within the present invention that a target to which the further targeting moiety of the conjugate of the invention is capable of binding, is a target that is expressed in an indication, meotiy in an oncology indication, more preferably in any indication related to oncology, where NTR is not expressed.

This compound is well suited to form amide, urea or thiourea linkages to other moieties especially for the addition of an adapter moiety. R is selected from the group consisting of hydrogen and C 1 -C 4 alkyl.

In an embodiment and as preferably used herein the term “mediating a linkage” means that a linkage or a type of linkage is established, preferably a linkage between two moieties. Also in accordance with the function of an adapter moiety in a conjugate of the invention, the reactive group s borne or provided by the adaptor moiety are of importance. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, jacrocyclic the original work is properly cited.

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phennanthroline

Study of Metal-1,Phenanthroline Complex Equilibria by Potentiometric Measurements

In an embodiment and as preferably used herein, C 1 -C 8 alkyl refers to a saturated or unsaturated, phenatnhroline or branched hydrocarbon group having from 1 to 8 carbon atoms. This includes stabilization of different oxidation states and modulation of the solvophilicity and electrophilic and nucleophilic properties of the metal ion [ 4 — 6 ].

Most of the research on the Phen derivates focuses on their catalytic, redox, photoredox, biological activities, and their supramolecular chemistry [ 13 — 18 ]. A non-limiting list of linkages as preferably used in connection with the phenanthorline of the invention and the characteristic type of atom arrangement is presented Table 3. It will be appreciated by a person skilled in the art that in particular an antibody, an antigen-binding antibody fragment, a camelid heavy chain IgG hcIgGa cartilaginous fish e.

The conjugate of any one of embodiments 40 to 31, wherein the second adapter moiety AD2, preferably prior to forming any linkage, is of the following structure:.

However, the software calculations rejected all species except and. Set,18, ; Cescato et al, J.

Phenanthroline

Imaging,34,NT analogs Alshoukr et al, Bioconjug. The conjugate of any one of embodiments 20 and 21, wherein the first targeting moiety is a com ound of formula 4. The experimental points were collected from pH 2 to In phenantrholine embodiment of the conjugate of the invention the target to which the further targeting moiety of the conjugate of the invention is capable of binding, is selected from group B as defined herein.

Orexin AB Antagonists: In one embodiment of the conjugate of the invention a compound 2in any of its embodiments, is present in the conjugate of the invention as targeting moiety TMl.

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